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When the New York Giants take on the Philadelphia Eagles on Sunday night, they will be without starting right tackle David Diehl, rookie nickel corner Jayron Hosley, and linebacker Keith Rivers, who have already been ruled "out" by head coach Tom Coughlin. The Giants will also be without No. 1 receiver Hakeem Nicks, whose offseason foot surgery has made him a question mark during the early part of the season. Nicks' added a knee injury to the injury report this week and, after initially being listed as "doubtful" to play against the Eagles, was downgraded to "out" on Saturday and will not make the trip to Philadelphia.

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Meanwhile, left tackle King Dunlap (hamstring) is out, which means Demetress Bell will make another start for the Eagles. After missing last week's loss to the Arizona Cardinals, wide receiver Jeremy Maclin (hip) is listed as "probable" and should be good to go on Sunday night.

Buffalo Bills running backs Fred Jackson (knee) and C.J. Spiller (shoulder) are listed as "questionable" for Sunday afternoon's game against the New England Patriots. Of the two backs, Jackson is the more likely to actually play on Sunday. For New England, they'll be without tight end Aaron Hernandez, who missed Week 3's loss to the Baltimore Ravens with an ankle injury that is expected to keep him out for four-to-six weeks. Edelman suffered a left hand injury in the loss to the Ravens and missed all of this week's practices.

Miami Dolphins running back Reggie Bush is "questionable" after suffering a knee injury during last week's loss to the New York Jets. Bush missed Wednesday's practice before returning on a limited basis on Thursday and Friday. If Bush is unable to play, Daniel Thomas and rookie Lamar Miller will carry the load against an Arizona Cardinals defense that could be without Darnell Dockett, who is listed as "doubtful" with a hamstring injury that kept him out of this week's practices. Dockett has missed just one game in his eight-plus seasons in the NFL. Other injuries of note for the undefeated Cardinals are tight ends Jim Dray and Todd Heap, who are "doubtful" with knee injuries, and safeties Adrian Wilson (ankle, groin), Rashad Johnson (hamstring) and James Sanders (calf), who were listed as "questionable" on the final report of the week. Quarterback John Skelton (ankle) is also "questionable", though Kevin Kolb is still expected to start.

The Detroit Lions' depth at defensive tackle will be tested with the absence of Corey Williams, who is "out" with a knee injury. Williams is tied for the team lead with two sacks this season. The Lions may once again be without safety Louis Delmas, who is listed as "doubtful" with a knee injury that has kept him on the shelf for the first three games of the season. For the Minnesota Vikings, linebacker Erin Henderson will miss a second consecutive week due to a concussion.

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Ron Rivera and the Carolina Panthers could be without a few key defenders on Sunday, with linebackers Thomas Davis (calf) and Jon Beason (shoulder) listed as "questionable" on this week's injury report. Davis was inactive last week, but is a Georgia native, University of Georgia alum and will be doing everything he can possibly do to play against the Atlanta Falcons.

The Cincinnati Bengals have six former first-round picks at the cornerback position. Four of them are on those this week's injury report, including 2012 draft choice Dre Kirkpatrick, who is listed as "out" with a knee injury that has prevented him from making his NFL debut. Veterans Nate Clements (calf) and Jason Allen (thigh) are "doubtful" and Leon Hall is "questionable" with an ankle injury. A banged-up secondary could be just what the doctor ordered for Blaine Gabbert and a Jacksonville Jaguars offense that ranks 31st in passing offense entering Week 4.

Linebacker depth is an issue for the New Orleans Saints, who will be without Jonathan Casillas and David Hawthorne for Sunday's game against the Green Bay Packers. With Hawthorne out, veteran Will Herring will start at linebacker. Compared to the Saints, the Packers are in great shape, health-wise. They'll be without safety Sean Richardson (hamstring) and cornerback Davon House (shoulder) is "questionable", but everyone else on the injury report, including starters Bryan Bulaga and Greg Jennings, is "probable".

Oakland Raiders wide receiver Darrius Heyward-Bey, who sustained a concussion after a scary hit from Pittsburgh Steelers safety Ryan Mundy that drew a $21,000 fine, was not officially ruled out, but has to go through the league's concussion protocols in order to be cleared to play. That hasn't happened yet and it would be a surprise if Heyward-Bey were active against the Denver Broncos on Sunday. The Raiders are pretty thin at the skill-positions as rookie wide receiver Rod Streater (eye, neck), tight end Brandon Myers (concussion) and running back Mike Goodson (hamstring) are "questionable". Myers is second on the Raiders with 15 receptions for a team-high 206 yards receiving this season. Broncos right guard Chris Kuper is listed as "doubtful" with a forearm injury and is not expected to play.

San Diego Chargers undrafted rookie left tackle Michael Harris is one of 12 rookie offensive players to not miss any of his team's snaps this season, but that could change as Jared Gaither proclaimed himself ready to play on Sunday against one of his two former teams, the Kansas City Chiefs. Signed to a four-year, $24.5 million contract on March 16, Gaither has not played since January 1 and is officially listed as "questionable" with a back injury. Whether or not the 6-foot-9, 340-pound tackle will be determined on Sunday, which is likely the case with kicker Nate Kaeding, who injured his groin during Friday's practice. That injury had the Chargers scrambling to add veteran Nick Novak, who replaced Kaeding during the 2011 season and was signed in time for the team's flight to Kansas City on Friday.

For the Chiefs, they'll be without tight end Kevin Boss (head) for a second straight week. Running back Peyton Hillis is "doubtful" with an ankle injury, while a quartet of wide receivers — Dwayne Bowe (groin), Steve Breaston (knee), Dexter McCluster (elbow) and Devon Wylie (hamstring) — are "questionable".

The San Francisco 49ers once again list wide receiver Ted Ginn (ankle) and running back Brandon Jacobs (knee) as "questionable". Neither has yet to play for the team this season. Joining them on the "questionable" line of the injury report is defensive lineman Isaac Sopoaga, who has ankle and knee injuries. Pro Bowl tight end Vernon Davis was a late addition and is listed as "probable" with a back injury. For the New York Jets, they'll likely be without rookie wide receiver Stephen Hill, who is "doubtful" with a hamstring injury. Tight end Dustin Keller (hamstring) has missed the last two games, but is "questionable" for the 49ers game, as are linebackers Bart Scott (toe) and Bryan Thomas (hamstring).

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The interior of the Seattle Seahawks offensive line could look different as right guard John Moffitt is "doubtful" with a knee injury. Moffitt had been splitting time with seventh round pick J.R. Sweezy, but left guard Paul McQuistan could be switching sides with 2011 first round pick James Carpenter stepping in at left guard. Carpenter was selected with the No. 25 overall pick in 2011 to be the bookend tackle to Russell Okung, but he made his first NFL start at left guard before moving to right tackle for the rest of his injury-shortened rookie season. During the offseason, the club made the decision to move him to guard on a permanent basis. One of the people Carpenter could face on Sunday is St. Louis Rams first round defensive tackle Michael Brockers, who could make his NFL debut. Selected with the No. 14 overall pick, the 6-foot-6, 322-pound Brockers is one of three first-round picks from this year's class who has yet to log a single snap in the regular season (Bengals cornerback Dre Kirkpatrick and 49ers wide receiver A.J. Jenkins are the other two.) The Rams have ruled left tackle Rodger Saffold "out" for the game, which means it's up to Wayne Hunter to keep NFC Defensive Player of the Week Chris Clemons from Sam Bradford.

The Tennessee Titans will be without starting middle linebacker Colin McCarthy (knee) for another week and quarterback Jake Locker may be without two of his top playmakers in the passing game. Wide receiver Kenny Britt (ankle) and tight end Jared Cook (shoulder) are listed as "questionable" for Sunday's game against the Houston Texans, who will be without wide receiver Lestar Jean (knee), but are otherwise healthy, listing 18 players as "probable", including Arian Foster (knee), Andre Johnson (groin), Johnathan Joseph (groin), and Matt Schaub (left shoulder, right elbow).

Washington Redskins safety Brandon Meriweather is listed as "probable" with a knee injury and could make his regular season debut with the club on Sunday. The Redskins could be without left tackle Trent Williams (knee) and wide receivers Pierre Garcon (foot) and Brian Banks (hip), who are "questionable" on the injury report. Though the Tampa Bay Buccaneers have Adrian Clayborn and Davin Joseph on injured reserve, the current active roster is quite healthy as second-year cornerback Anthony Gaitor (hamstring) is the only player not expected to be available to Greg Schiano & Co. on Sunday.

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